
Frontline spray is safe to use on the bitch and pups from two day of age, but not the Spot on treatment.
You may have to start weaning pups as soon as their eyes are open if weight gain slows sown or they seem hungry. You can soak their puppy food mash it and add it to bitch milk replacer, any of the proprietray puppy milk formulas are good, but not cows milk.
The bitch will need at least 4 times her normal amount of food if not more, basicaly as much as she will eat every couple of hours, at least 4 meals a day with plenty of water.
Because theri mouths can get sore from all the cleaning I soak their complete food in as much water as it will take, this encourages food and water intake.
As the others have said Vet bed is almost a necesity as it keeps Mum and pups dry with all fluids pasing to the paper beneath. With that many pups you will be hard pushed to keep them dry and clean without it.