http://www.noahcompendium.co.uk/Virbac_Limited/Alizin_30mg_mL_solution_for_injection/-57090.htmlPharmacodynamic properties
Aglepristone is a synthetic steroid counteracting the effect of progesterone by competing with this hormone at the level of the uterine receptors, resulting in abortion (or resorption) within 7 days after administration.
Aglepristone does not modify progesterone, prostaglandins, oxytocin or cortisol plasma concentration within 24 hours after its administration but it induces a discharge of prolactin within 12 hours.
In vitro, the affinity of aglepristone for the progesterone receptors in the uterus of the dog is 3 times higher than that of progesterone.
The relative binding affinity of aglepristone to glucocorticoid receptors is similar to that of dexamethasone but aglepristone has antagonistic properties.