
here's some ideas.
there are some great homeopathic remedies that work wonders for travel sickness.
A cage is a good idea as he will feel safer in a cage even though his space is restricted ~ he will feel more comfortable.
take him for very short trips to start & always to a nice place, drive him to the park, drive him to the woods. Try & avoid driving him to the vets. You need to get a good association with the car.
You could try feeding him in the car if he loves his dinner. Take his food bowl to the car, pop him in, feed him & back inside.
I would strongly recommend the homeopathic remedies from personal experience, I have seen very sick dogs almost miraculously "healed" after a tiny white magic pill ! :)