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Topic Dog Boards / Breeding / haemophilia A
- By molly [ru] Date 02.10.08 00:40 UTC
hi all sorry  having a really dizzy day today, please excuse my stupidness.can a breeder explain this to me i know haemophilia is a sexed linked condition , and that all male breeding stock should be tested haemo clear before being mated, i beileve this shall prevent any male puppies  from contracting the condition  from there sires,. and any females from being carriers quote me if i am wrong.If this is the case then why do some breeders that get there stud dogs tested haemophilia clear only to state in there endorsements that progeny can not be bred from unless at a year old hips are scored and under the breed average, and that all male puppies shall be haemophilia tested clear before the endorsments are lifted, i do feel a bit confused as i thought the whole point of them having there stud dogs tested was to prevent the male puppies from having it, i have seen this a few times and its annoying me now maybe i am just being thick at the moment, any comments would be appreciated, i beileve also that von willebrands desease can be contracted from either sex and is more severe than haemophilia A.
kind regards in advance molly.
- By wendy [gb] Date 02.10.08 07:09 UTC
i think that some breeders do not want their pups bred from (i am one myself) unless they know that all relevant health tests are carried out and the pups are a suitable age to be bred from, in females it is 2 years of age, in my opinion.  Personally I will do all that is possible to make sure that any of my pups have the best home possible and would not want them to be continually bred from, even if all their health tests are good.  It sounds like the breeders are just being very responsible.
- By Jeangenie [gb] Date 02.10.08 08:04 UTC

>i thought the whole point of them having there stud dogs tested was to prevent the male puppies from having it,


In humans, haemophilia is carried down the female line, with only males being affected. So although the stud dogs are tested clear, the bitches aren't ...
- By Moonmaiden Date 02.10.08 08:41 UTC

> and that all male breeding stock should be tested haemo clear before being mated, i beileve this shall prevent any male puppies from contracting the condition&; from there sires,. and any females from being carriers quote me if i am wrong


Yes you are wrong

The gene for Haemophilia is carried on the X chromosome which male dogs get from their mother. There is as yet no reliable DNA test to detect female carriers. It is therefore very important that all males are Haemophilia tested BEFORE being used at stud & passing on the gene to his daughters who could then passit on to their offspring.

Haemophilia is not"contracted"it is inherited from the parents, feamles who inherit from both parents are very rare & usually die in utero(ie before birth)& are reabsorbed. Affected males inherit/Haemophilia from their mother this is why ALL males have to be tested until there is a reliable test for females for Haemophilia. Carrier females inherit it from either parent.

VWD is a form of Haemophilia & has difference forms & can be acquired(but not contracted-subtle difference)for which there is a DNA test for both sexes

In Germany although they have not stopped Haemophilia being inherited by females from their mothers, by insisting on having all males tested & affected dogs either not having their progeny registered/or not being used at stud(the norm)the incidence is reduced dramatically.
- By molly [ru] Date 02.10.08 09:22 UTC
thankyou moonmaiden for your reply my head feels much clearer this morning i thought i was barking, you have made it very clear of how haemophilia is inherited, i did not realise that there was no test to find out if a female was a carrier thats what confused me, wrongly  i thought if the sire was clear all his male puppies would be,i understand now thats why breeders want there male puppies haemo tested makes sence incase they have inherited it from your dam, thankyou ever so much for this imput, molly
- By Moonmaiden Date 02.10.08 14:50 UTC
No problem-I'm a GSD owner(not currently though :-( ) for the best part of 50 years & it is a subject close to my heart
- By ho1mer [gb] Date 03.10.08 08:28 UTC
hi molly,   also there is a possibility that a male could have a mutant haemophilia gene which didnt come from either parent but can still be passed on.
- By Moonmaiden Date 03.10.08 08:47 UTC

> also there is a possibility that a male could have a mutant haemophilia gene which didnt come from either parent but can still be passed on


Think I covered that

VWD is a form of Haemophilia & has difference forms & can be acquired(but not contracted-subtle difference)for which there is a DNA test for both sexes
- By molly [ru] Date 03.10.08 10:17 UTC
thankyou for your reply,
Topic Dog Boards / Breeding / haemophilia A

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