I bred my bitch on June 13 & June 14, and this morning I saw she had a clear discharge.  It seems early to me.  Could a larger litter produce more hormones to bring this on sooner?  I thought usually it happens around 5 weeks.  Any advice?

Hi Cufola !!  Don't think I would worry too much about this....  My bitch had a clear discharge throughout her pregnancy the last time - from about two weeks - and went on to give birth to 5 Pups.  If you are really worried about it I would make a quick visit to the vet just to set your mind at rest.