
My dog had a histiocytoma as well. The vet gave me some cream (I can't remember the name, but I believe it may have been a steriod lotion) to rub on it twice a day. I am not sure it made any difference whatsoever, but nonetheless the histiocytoma resolved itself and has not reappeared.
Unless your vet thinks there may be an infection or the tumour has ulcerated, antibiotics are of no benefit for histiocytomas in terms of making them disappear any quicker.