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Topic Dog Boards / Health / Frontline Combo ~ Adverse Reactions
- By Harmony Date 22.06.06 22:24 UTC
Has anyone used this & seen any adverse reactions?
- By Missie Date 22.06.06 22:29 UTC
Not used it myself. Why whats happened Lyndsay?
- By Harmony Date 22.06.06 22:40 UTC
Hi, I did all the dogs yesterday (except Daisy as she's nursing), 3 of them had the 10-20kg spot on, 2 had the 20-40kg spot on.  I've used this before so certainly didn't expect any problems.

Tonight giving Molly a fuss & felt a funny scab where the spot on had been applied (between her collar & should blades).  On further investigation it looks like a burn :(  It can't have come from anything else.

Someone has suggested that it can cause a reaction if shampoo's & grooming sprays have been recently used but it's been about 2 months since Molly had a bath & although she gets brushed 2-3 times a week, I don't use anything on her.

I've cleaned the "burn" & applied Colloidal Silver which looks to be calming it down.  I've also started her straight onto Synulox just in case as it does look nasty.  I will obviously take her to the Vets tomorrow but thought I'd ask in the meantime.
- By Missie Date 22.06.06 22:50 UTC
oh, no, sorry never used the combo though have used the spray in the past and thats never been a problem. Hope it clears up soon :)
- By Harmony Date 22.06.06 23:14 UTC
Thanks Missie.  I've never had problems with Frontline either.  I've got the Suspected Adverse Reaction report form for the VMD so will take that with me to the Vets tomorrow & see what he says.
- By supervizsla Date 23.06.06 08:04 UTC
I have heard of some dogs having reactions to the combo and not the normal frontline.
They all got the burn type reaction.
I heard this at the vets i work at.
Sorry not much use but just to say that i have heard of it
- By MariaC [gb] Date 23.06.06 10:32 UTC
Hi
My 3 year old GR went very strange after using the frontline spot on last December.
 
When I say strange what I mean is apart from the intitial running around and trying to rub his back/neck on the floor, he panted and stared at the wall for a few hours, almost as if he was in a trance.  We couldn't do anything with him at all, we tried to reassure him but he wouldn't have anything to do with us - so I slept on the floor with him that night.  The following morning he was fine.

Looking back I now realise this was a sign that he was sensitive to certain substances.  The vet didn't really think it was a problem when we told him about it before his fatal vaccination.  My opinion is that if a dog or cat reacts to any drugs etc we use on them, their immune system is compromised in some way.

The breeder of our new puppy advises using the spray Frontline which she said is much more gentle. 

I think whatever we use we need to do so with caution!

Maria
  

  
- By Harmony Date 23.06.06 10:56 UTC
Thanks Maria.

You're right about us using caution.  Even though I've used the Combo before & normal Frontline for years, I still always read the box & instructions at least twice!!

It is possible that even though Molly has been pretty much back to normal for 2 weeks (I wouldn't have treated her had I had the slightest doubt), her immune system is currently compromised resulting in the reaction.

The Vet did say the spray can be more gentle but you have to remember to glove & mask up!  I think I will look at more natural remedies for the future. 

Thanks again.
- By Annie ns Date 23.06.06 11:05 UTC
I won't use any of these things and just put a little garlic in my dogs' food - seems to keep them bug free. :)
- By Harmony Date 23.06.06 11:16 UTC
Thanks Annie.  My dogs get garlic everyday!! 

Unfortunately there are a lot of fleas & ticks about at the mo plus I have 3 cats that like to bring me presents :eek:
- By Annie ns Date 23.06.06 11:39 UTC
From what I've heard, dogs and cats seem to still get fleas/ticks even after being recently Frontlined?  Do you treat the house as well?  A friend of mine who doesn't use chemicals on her dogs does 'fumigate' her house.  Blowed if I would use anything on my dogs that I had to glove and mask for! :eek:
- By Harmony Date 23.06.06 12:16 UTC
Doesn't matter what you use, fleas can & will jump on your pets but if they're protected then one bite & they're dead!!

One of my cats is seriously allergic to fleas but by keeping her Frontlined she's always ok.  I have previously tried other products with her including natural remedies but Frontline is so far the only thing that works for her & it also strangely enough has to be the spot on, the spray doesn't have the same effect :confused:

Yes I treat my house.  I don't currently have many carpets but they do get treated.
- By Harmony Date 23.06.06 10:48 UTC
Thanks Anna.

I've now spoken with the Vet & he actually thinks it's probably an injection site reaction brought on by the Frontline Combo.

The Vet agree's that it all needs to be reported.  He told me that he's just had 2 other site reactions, one to a vaccine (suprised he told me that!) & the other to an antibiotic jab ~ he said that both cases took 2 weeks to show.

Obviously when Molly was hospitalised nearly 3 weeks ago, she was given antibiotics & painkillers although I thought these had been given through the IV.

This morning the reaction looks a lot calmer & is pink rather than the angry red.  There is still a little weeping from the centre.  The Vet is happy for her to continue on Synulox & agree's that the Colloidal Silver is the best cleanser.  (My Vet has been full of suprises this morning, maybe he heard about my complaint ~ lol!!)  He also said that he would leave a message for the Senior Partner when he returns on Monday.

Thanks for everyones replies :)
- By Christine Date 23.06.06 11:18 UTC
Glad its looking better B/P & your vets going to report it :)

Where do you get your C/S from? I make my own & know a woman in UK who makes her own as well, has the same machine as me, I`m pretty sure she sells it cheaper than the shops & the qualities far better. I can give you her email if you want :)

re vax injection site reactions, these have been known for a long time in the cat & they are now being found in dogs :(
- By Harmony Date 23.06.06 11:25 UTC Edited 23.06.06 11:35 UTC
Thanks Christine.

The CS I have here at mo is from Rivers of Health but I desperately need some more!  Is it Brenda who you're thinking of over here?  I've got her web addy somewhere ............. here  Will give her a call or email.

For anyone that's interested Brenda has some great offers on & I've just put in an order for some more :)
- By Christine Date 23.06.06 11:43 UTC
Yes thats her :D Very nice lady, take her up on her offers, its good quality stuff! :D oh & tell her I said hello :D
- By Brainless [gb] Date 23.06.06 10:55 UTC
I would suspect it is because it is more concentrated than the spray.  Mine reacted with a bit of redness and irritation when I brought them back to UK on Pet Passports after a show, only been the once, have used the Spray at other times which is more dilute hence you use more per treatment but it goes all over the dog not just one spot.
- By spanishwaterdog [gb] Date 23.06.06 12:34 UTC
I use the spray very rarely with my dogs, prefer to use garlic.  Anton had a reaction to the spray the first time that I used it but nothing since.

A vet once told me that every dog and cat will have at least one flea on them at all times! 
- By Harmony Date 23.06.06 13:11 UTC
Update!!  I've just had a phone call from Merial Animal Health who have taken this seriously.  Apparently now their Vet will speak to my Vet, they will keep their reports, the VMD will send a copy of my report to them (posted today), they will marry them up, investigate & come back to me!
- By Christine Date 23.06.06 14:17 UTC
Result!!

I don`t think you`ll hear anything back from VMD, its a closed shop & they don`t discuss the reported reactions :rolleyes: well thats what they told me & I never heard back from them once they`d accepted it :rolleyes:

I did hear from Merial tho, funnily enough it was their vax my pups had the reaction to, yes had a few words with them.......
- By spellmaker [gb] Date 23.06.06 14:41 UTC
Can I jump in here please with a question my dogs are due to be treated with advantage which I get from my vet , one of the dogs has a sebaceaus cyst at the moment on her neck and I,m just not sure if I should use the treatment on her while the cyst is there.Im not sure if it will harm her by putting on the flea treatment or if by not using it running the risk of a flea infestation will do her more harm.
All my dogs have always been kept up to date with flea and worm control and I don,t want to stop or delay the regime really. any comments from anyone?
Sharon
- By Isabel Date 23.06.06 14:43 UTC
Not sure whether a sebaceaus cyst, which is after all just a collection of sebum, would be likely to bring about an alergic reaction if there wasn't going to be one otherwise but I think you should check with your vet if you are concerned.
- By Harmony Date 23.06.06 16:40 UTC
I would have thought your dog would be ok as long as the cyst isn't open & you don't put the spot on, on top of the cyst but your best bet is to take your Vets advice.
- By Harmony Date 23.06.06 16:38 UTC
On the VMD form it just says that "Receipt of this form will be acknowledged" & I suppose in reality I don't expect any more than that.  The lady I dealt with at Merial was very nice & very helpful so will see if they come back to me like she promised.

I've kept a copy of everything & if I don't hear anything within 28 days I'll follow it up with a phone call.

Thanks Christine :)
- By Christine Date 24.06.06 08:58 UTC
Yes B/P thats what I got, a letter acknowledging it with a reference number. On defras site somewhere you can find a table with all the adverse reactions listed for different things but usually a year or 2 behind :) Your will be 1 of them :D

Hope its healing nicely now by the way & not giving any trouble :)
- By Harmony Date 24.06.06 09:26 UTC
Thanks Christine, it is looking much better again today & Molly seems a lot happier :)
- By lucyandmeg [gb] Date 24.06.06 09:48 UTC
Probably not relevant but was the product in date? I know the older it is the more toxic it can become.
As i say you probably checked this already though.
- By Harmony Date 24.06.06 20:44 UTC
Absolutely!!  It still had 12 months of date on them.
- By Harmony Date 28.06.06 11:55 UTC
Just to say I had a letter from the VMD this morning :cool:  I have to say it reads like a very standard letter :rolleyes:  At least they've acknowledged the form.  It does say they may write to me again but that seems fairly standard?  They also enclosed 2 more reporting forms should I need them :eek:

Anyone just thought I'd update you :D
- By Harmony Date 28.06.06 21:34 UTC
As an add onto this, the lady from Merial phoned me this afternoon.  Apparently their Vet has spoken to my Vet & along with that & the info from me they say there is a definite need for this to be investigated further & they also will be putting in a report to the VMD.  I asked if I'd hear anymore back from them & she said that any further correspondence would be through my Vet.
- By Christine Date 29.06.06 04:41 UTC

>>>& they also will be putting in a report to the VMD.<<<  Once they`ve been informed of a reaction they have to report it to the vmd B/P.


Hope the reactions cleared up now tho & thanks for updates :)
- By Harmony Date 29.06.06 13:56 UTC
Thanks Christine.  The reaction site still looks a mess but is very slowly reducing in size.  I have noticed though (& did tell the lady from Merial) that under the skin is very hard tissue.  The Vet isn't overly concerned at mo so we'll see what happens.

Thanks again :)
- By Admin (Administrator) Date 06.09.06 08:12 UTC
Received:

SCOT BERMAN
ARIZONA
USA

bgschevra@yahoo.com

I AM WRITING IN REGARDS TO POSTING ON YOUR FORUM REGARDING FRONTLINE. THERE WERE SOME POSTING ABOUT DOGS AND ANIMALS  THAT HAVE  HAD  BAD REACTIONS LIKE OURS.   OUR DOGS  HAVE BEEN SEVERELY CHEMICALLY BURNED, THAT WILL TAKE  MONTHS TO  RECOVER. MY  BLUE FEMALE ALMOST DIED.  I HAVE PHOTOS TO SEND, IF ANYONE WOULD LIKE TO SEE.
WE ARE  LOOKING  FOR OTHER EXAMPLES OF THIS  OCCURRING TO.
MY  NAME IS SCOT AND WE ARE IN PHOENIX AZ.
PLEASE HELP US !
- By Isabel Date 06.09.06 13:35 UTC
Is the product exactly the same in the US, though?  Even if the active ingredients are the same the suspension medium might vary, different regulations and all that.
- By Cairnmania [gb] Date 07.09.06 07:40 UTC
It is Isabel.  I bought Frontline Combo/Plus last year in the U.S. and checked to makes sure it is the same.  It's actually manfactured in France, not that makes a difference, of course.
- By Isabel Date 07.09.06 12:30 UTC
Is everything listed though, or just the active ingredients?
- By Cairnmania [gb] Date 08.09.06 11:46 UTC
Isabel,

I no longer have the packing that I bought in the U.S., so I cannot doublecheck now.    The Frontline Combo sold in the UK lists all the ingredients, including the liquid suspension (looks like mostly Ethanol) for the active ingredients.  I assume the U.S. packaging did too, althought at the time I was only concerned about active ingredients.

Stacey
- By Harmony Date 07.09.06 17:54 UTC
Molly still has a burn type scar & something else that is becoming a little concerning is that Molly seems to have started to go a bit senile ~ coincidence to the reaction?  She's 11 1/2yrs so no spring chicken, she's pancreatic so have to keep a close eye on her but for her mental health to be taking such a dip I can't help but wonder if it's the chemical reaction?

Anyone got any thoughts on this?  My Molly seems to have suddenly gone very old :(
- By Christine Date 08.09.06 13:25 UTC
It certainly won`t have helped her any at all B/P :( You`ll never know for sure but the chemicals/toxins would have gotten into her system & could have caused neurological probs or exacerbated any already there :( 

Try milk thistle to help her liver get rid of any toxins she may have.

I`d supplement her with highest doses of fish body oils, vitE & vitC. Vit e is also good for skin so might help scar. Add a good vitB complex daily, they help with brain function & tincture of echinacea to help her immune system:)

http://lpi.oregonstate.edu/infocenter/vitamins.html
http://www.mercola.com/2005/may/11/pet_vitamins.htm
- By Christine Date 08.09.06 13:26 UTC
ps   make sure to use natural form oif vitE & you can also use it neat over the scar itself to help heal it:)
- By bint [gb] Date 09.09.06 07:43 UTC
Not seen skin sensitivity reaction but pup had a strange reaction to combo last year. He seemed to be in a daze, as if asleep sitting upright & although was able to stagger backwards when I shouted of him he seemed confused, as if semi-conscious for a few minutes. We thought he was going to collapse or perhaps take a fit but within minutes he was back to his naughty self wondering what all the fuss was about. Vet couldn't find anything wrong with him, said he'd never known any problems with frontline combo but did add it to the pups records as ?frontline allergy. Dog has been fine since. Because it lasted only a few minutes & then the pup was ok, I wonder how many other dogs have had similar reactions without the owners knowing?
Hope Molly's ok
Topic Dog Boards / Health / Frontline Combo ~ Adverse Reactions

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