
Got this off an e-mail list a few weeks ago, wouldn't it be wonderful eh:
This is exciting -- the CKCS will be one of the few breeds to have a
full genome scan. As noted this is expected not only to identify genes
associated with SM and hopefully provide a genetic test, but also
identify the genes for MVD. The Canadian and UK researchers pushed very
hard for this, backed by some helpful support from breeders
internationally.
CKCS breed will get full genome scan
UK-based researchers Clare Rusbridge and Penny Knowler and their
Canadian collaborators Guy Rouleau and Berge Minassian have been
successful in their submission to the Mammalian Genotyping Service at
the Marshfield Clinic in Wisconsin (USA) for a full CKCS genome scan.
The research is initially into syringomyelia but hopefully will be
extended to looking for candidate genes for MVD as well.
The research, undertaken by a joint veterinary and human medical group,
will benefit both 'man and his best friend'. Syringomyelia in CKCS is
an excellent model for research into the condition in humans, and human
geneticists are interested in validating findings from the CKCS
research in humans. Finding the gene and learning how it works would
help the understanding of the disorder for better diagnosis, clinical
management and ultimately, prevention. For biologists, these studies
will provide new insights into the poorly understood process of normal
development of craniocerebral structures of the central nervous system.
The researchers say that many people worldwide will benefit from this
research -- and are pleased that so many 'ordinary' people worldwide
are contributing to make it possible.
The genome scan will identify markers which can then be used to
identify the gene/s responsible for the disorder causing syringomyelia.
The same team have already been successful in identifying the canine
gene for Lafora's disease. The research is expected to take several
years but the first stage will hopefully produce a DNA test which will
enable informed breeding decisions.
The researchers say that due to the generosity of clubs, research
projects and individuals, they have collected enough DNA samples to
start the genome scan. Therefore they no longer require DNA from CKCS
dogs with syringomyelia. However, the researchers are still anxious for
DNA from dogs of breeds other than cavaliers that have syringomyelia.
The researchers acknowledge that the entire project could not have been
undertaken without the support of the UK DNA Archive for Companion
Animals.