
Basically, no! It's not usually anything to do with the breed, rather than the individual. If your great-uncle's JR had ever been ill-treated by women she would be more likely to distrust them. They can certainly smell hormones though, and I would guess that this particular bitch didn't view human males as mates (wrong species, wrong pheromones!) she might view oestrogen-laden females as rivals. Maybe your great-aunt was post-menopausal, and therefore not secreting hormones?