I am so worried. My Rottie (9 1/2) had a mammary strip at the beginning of October last year, 3/4 of the wound healed but the remainder, (despite re stitching), refused to heal. The swab results showed Ecoli, and Staphyloccus Pseudintermedius, with a whole load of resistant antibiotics listed. My vet said the wound would need to heal by granulation, and advised me to use Manuka Honey, (which I researched and found a high grade 514 upwards would help). Sadly, she has had skin problems for most of her life, (including a recurring psdemonas infection in a foreleg), and has numerous allergies, (seen a dermatologist). Eventually the mammary wound healed, but now she has lesions appearing, deep pyoderma, some discharging some not, (and we're obviously visiting/keeping in touch with my vet), who has advised to keep using the Manuka honey. Does anyone have any experience with antibiotic resistance that could share their experience, as the manuka honey is just not helping now.

Honey is good for wounds as it's naturally antiseptic, however it's no substitute for antibiotics or antifungals. Personally I'd go back to the vet and see if a different antibiotic helps or getting them to do another culture to get a specific antibiotic.

I should have said that we've already tried two different abs  that have been  recorded on the last two swabs as 'sensitive' but they've not worked. The Manuka honey grade I'm using (540) is supposed to help with MRSA, (and MRSP, which is the dog equivalent). I am due to speak to my vet tomorrow, I'm just looking for help, and perhaps a miracle.

https://www.thebellamossfoundation.com/  these people may  have some advice. Also have u spoken to the dermatologist again ? Maybe some information from that route too

I would be getting a referral to a skin specialist who can also do tests to see what antibiotics are suitable to be given and anything else to help her skin heal. I wouldn't be messing about with a regular vet, see a specialist pronto

If the previous dermatologist knows the history and has treated your dog i agree with sj . A specialist dermatological referral

Thanks everyone, will contact Dermatologist first thing tomorrow. Tbh seem to have lost all my common sense  with worry

Sounds like a very difficult spot. Fingers crossed for you and your fur baby. Hopefully the vet tomorrow will have a few more things up their sleeve