Hi. Could some please explain these results for me? Dad - HD-A, eyes free, MDR+/+, DM +/-
Mum - eyes free, MDR +/+, DM +/+ or +/-- by parentage
Looked on Laboklin site, but that has 'Clear', Carrier' or 'Affected'. Does the '+' mean positive for the condition?, and the '-' mean negative for a condition? So a +/+ would mean the dog has a positive from both parents, and therefore 'affected', and a +/- means carrier? Or am I completely barking up the wrong tree? (excuse pun). This is for a rough collie import.
Thank you.

Actually, don't worry. I've finally found somewhere that has this information. Thank you. It was the opposite of what I thought :)

Normal/clear = +

Logically you would never breed from 2 affected/carrier parents

Don't forget Rough Collies also need a CEA(CH) DNA test & at least 1 parent( perferably both)normal result.

Thank you for your reply. So would the eyes free part, not be CEA/CH? Or does that sound like just BVA type eye test? the +/-- also mean carrier? (with the two --)

Sorry for my ignorance. Just want to understand the tests fully, and finding it quite difficult to find a great deal of info on these results. I know if the dad is +/+, then it means he is clear/normal, but just wondered why the +/-- by parentage is needed, unless it means anything else, or has some significance. Just want to learn what all these things mean. I understand the tests in the UK, as they are so easy. Yes I can see logically now that +/+ wouldn't have been positive, and people wouldn't blatantly be advertising pups that would clearly be affected. :/ I am feeling rather stupid for even thinking that I blame it on lack of sleep I did actually try to delete that question when the cogs started turning, but I'd left it too long and couldn't delete it.
I still would like to know what the two minus signs (+/--) mean though please, if you wouldn't mind humouring me, please. Thank you.

A wild guess on the two minus signs - unknown/no data?

Ah, ok, thank you :)

Sorry for being so unknowledgeable, and thank you all for your help :)

Sires results are hips grade A which is an european result but a good one MDr +/+ means clear /Normal
Dm +/-  means carrier i.e carries one copy of the gene responsible for DM  and eyes free would mean no sign of any condition at  clinical examination by a specialist vet
Mum would be similar Clear for MDR and either clear or carrier for DM due to her parents results but not apparently tested in har own right and clinically eye tested rather then a DNA result

Thank you so much for all your help :)

The eyes free will be for clinical PRA test

CEA(CH)is different from other eye conditions in that a dog can be affected but the condition can "go normal"after 14 weeks so that the dog appears to be normal, but isn't. Before the DNA test was available puppies had to be screened before 14 weeks to be sure they were not affected, therefore any CEA(CH)clinical test in an adult can give a false negative.

Especially in Rough/Smooth collies & Shetland Sheepdogs the DNA for CEA(CH)is essential as the condition is widespread in these breeds

All breeding dogs should be either DNA tested Normal or Normal by inheritance(ie both parents DNA tested normal or Normal by inheritance), however one parent could be a carrier for puppies not to have CEA(CH), but then all the puppies need to be DNA tested for their status to be known. I personally would not consider Rough Collie from unknown DNA status parents for CEA(CH).

You need to find out if the parents or dog have DNA status is known

The DM status:-

-DDC Veterinary’s DNA test reveals one of the 3 possible genotypes for degenerative myelopathy:

CLEAR (those having 2 copies of the normal allele and appear to be normal).
CARRIER (those having 1 copy of the normal allele and 1 copy of the mutation and most appear to be normal).
AT RISK (those having 2 copies of the mutation and will likely show clinical signs.)

Ah ok :( I didn't realise this. Thank you so much for your detailed help. I will contact them now to see if this has been done. Thank you.

So if I bought a pup over 14 weeks of age, and had it dna tested, the CEA could come back as clear/ normal, even if it isn't ? These things are so complicated if dna can show normal/ clear when it's not after 14 weeks :(

No the DNA test would come back with a true result its the clinical eye exam that wouldnt always show CEA after 14 weeks .

Ah ok thank you :)

Ditto above.

Must add if I was buying a puppy from aboard I would want a parental DNA profile done to ensure the puppy I was getting was the offspring of the parents on it's registration. This is now required for all GSD puppies in Germany registered with the SV after a scandal some years back with false pedigrees

:( Oh ok, thank you