Hi so i am after some advise, i have a litter a 9 [large breed] puppies, my girl had 12 but unfortunately the last 3 she gave birth to came out still born. this is her first litter. The first puppy that she gave birth to came out struggling to breathe taking gasps every so often, he was the biggest by far, over 150grams bigger than the rest! however, he wouldn't suckle from mum for the first 2 days so never had mums colostrum, i fed him every 2 hours for the first 48 hours then out of the blue he started suckling on mum when 2 days old, no way near as much as the others but he was doing it! so i just topped him up every few hours with small amount of milk replacer. At 11 days old he started having a bit of a sticky eye (eyes still closed) so he went to the vets and he had a course of synulux antibiotics for a week (which he finished monday) and it has all cleared up well. vet was quite happy with him and said not to worry that he is thinner than the rest. He is now 20 days old and he is still so weak, very think and not really suckling. he is literally suckling for 5 minutes every 4-5 hours and refusing to take milk from me too. he has been wormed with the 3 day panacur, last day today. so may have gone off his food more due to that. he has been crying a lot the last couple of days too. the other 8 puppies are very big and plump where as he is small and quite frail, when you pick him up you can feel his rib cage in your hand, but vet still doesnt seem to be worried about him! he isnt dehydrated so he is getting milk, just not enough as not putting weight on.
he has had the puppy stim stuff but i found it doesnt make that much difference or give him anymore energy.
he takes a while to settle, always wanting to clamber ontop of the other pups, especially when they are suckling he goes and lies on top of their heads!

i have always made sure he goes on the teat first but he just really isnt interested in food what so ever!

any advise would be great!

any advice is much appreciated???

Sorry I can't give advice but how is puppy now ?

Sometimes, with some puppies, it's just not meant to be.  Sometimes breeders struggle on with a pup which is clearly sick, trying to nurse the pup back to health - and perhaps the pup survives, but with defects (physical or mental).  The breeder puts so much effort into saving that one puppy that the rest of the litter get less attention.  Sometimes it is not clear what the problem is, until the pup is older. 

From what you describe, him being blue at birth, it sounds like there was a loss of oxygen to the brain.  When pups don't gain weight, it's usually a sign there is an undiagnosed problem.  The best thing for putting weight on, is tube feeding.  There are lots of good videos showing how, on YouTube - look for Myra Savant-Harris YouTube video.

When a pup won't nurse to get the collostrum, you can express it from the bitch and tube feed it to the puppy if necessary - to ensure they get those antibodies for a strong immune system.

thanks for the reply, he was off his food and not wanting to suckle again yesterday so back to syringe feeding - been to the vets this morning with him and he's now 1.7kg so put 400grams on in 10 days which the vet was very pleased with. he said the physical examination he is healthy with a good strong heart beat. he has been given oralade which is electrolytes and zantac to keep his gut well, he said he could just be the runt or he could have something underlining which cant be looked into for another few weeks due to his age - so just keep up syringing him and with the oralade but hes done very well to get to 3 weeks old and he called his weight gain 'significant' so i am pleased with that!
So we are taking every day as it comes at the moment, trying my best for the little one
i spoke to the vet re tube feeding as currently i am syringe feeding and almost force feeding as he doesnt want the milk, obviously force feeding slowly not to aspirate. but the vet said not the tube feed as hes doing fine as he is

Ok, but do know that the majority of UK vets would not know how to tube feed and are not repro vets.  Baby animals can go downhill fast...

I'd subscribe to the what will be, will be.   We had a puppy, years ago, the so-wanted lemon/white bitch I'd hoped for and the only one that wasn't a standard tricolour in the litter.   We named her Honeydew.  She had a very slow birth and as time went on, much as weight-wise she was keeping up with the others, just looking at her expression told me she was 'slow' and had probably suffered with oxygen starvation at birth.   We kept her to around 18 weeks and as over time, it was clear she wasn't right - no control at all over her urination or bowel movements and with odd movement compared to the others, after a long talk between us and our vet, we all decided that the kindest thing for her was to pts, with dignity.   I couldn't have homed her because the lack of control over her bodily functions would have tempted the patience of the best of owners and I couldn't think of her being mistreaded because of that.   And in all honesty, keeping her as a very demanding passenger in our small pack wasn't going to be easy either.   Heartbreaking but I know we did the only and right thing, for her circumstances.   RIP little Honeydew.

Message to your, OP, situation, give it time and see how he is later on.   Is all you can probably do if the vet has nothing to offer.   As said, we all strive to bring each and every puppy we produce through the early puppy days and out into the world, but sometimes it's just not meant to be.

i am trying my very best and not giving up. he has perked up with the electrolytes little and often and has been suckling. only time will tell, he will stay with me for life if he pulls through and carries on