I had this with my bitch while pregnant she was not particularly big, but towards the end I was literally following her round with a mop. I took a urine sample in to the vet and they did tests and also sent a sample to the laboratory for testing and to grow a culture. All came back normal.
She whelped 9 large puppies, and was still not able to hold on for long, sometimes had wet before I could unlock the door, but a couple of weeks after whelping she went back to her pre-pregnancy routine.
Now 9 weeks after her puppies were born, everything is fine, but I think I need to invest in some new carpet !! Good job I had vinyl laid in most areas.
Would definitely take a urine sample in to the vets just for peace of mind. When I had my bitch scanned the vet said it looked like the pups were pressing around the bladder.