Hi new to all this but thought someone may be able to help me, what is the difference between GPRA and CPRA i have had my bitch dna tested for prcd PRA. I am also booked in next week for the KC/BVA ISDS scheme including the gonioscopy test. Because she has been dna tested they have told me that she only needs the gonioscopy test. Will the dna test have covered the GPRA and CPRA.

GPRA is really an umbrella term, as originally it wasn't realised that several different genes caused the same seeming disease.  prcd-PRA is one of the forms.

CPRA is different and is in fact a metabolic disorder that then causes the eye problem.

So they are different.

We also have prcd-PRA DNA test for our breed but still need annual eye testing for other forms (in the past it was known we had at least two types identified, a third early onset type seems to have disappeared) and to identify any other eye disease that may emerge.  We do have cases of Glacuoma but sadly no way to identify a predisposition.

Thank-you for your help. So i should still insist on the KC/BVA eye tests aswell when i go next week, to make sure everything is covered?

Yep, you get charged anyway.

Hello Martingale,

Assuming your dog is a BC, the DNA test mentioned by the breeder will be for CEA (Collie Eye Anomaly ). I hope you were provided with evidence that parents were tested and results given. If either parent is a Carrier of the gene for the condition and you are intending to breed from her, she will need to be tested  -she would have a 50% chance of being a Carrier.
The BVA /ISDS eye test is also looking for PRA and PLL (Primary Lens Luxation ) which are  eye conditions that can affect the breed. Make sure when you go for the test that they do not put in the midriatic drops which are used to dilate the pupils prior to regular testing The opthalmologist will put anaesthetic drops into her eyes before inserting a special lens to perform the gonioscopy and will afterwards put in the midriatic drops for the rest of the eye test. I've been a lot of clinics where the owner has forgotten to remind the assistants that gonioscopy is going to be done but too late..the midriatic drops have been put in and the test has to be postponed.

Your girl should also have the results for two more serious conditions for which there is a DNA test ( meaning parents should have been tested or are clear by inheritance ). These are TNS (Trapped Neutrophil Syndrome -a fatal condition attacking the immune system ) and CL (Ceroid Lucofuscinosis which attacks the nerve cells -also fatal )

Hope all goes well.

Hi Jan. Not a BC she is a WCS. She has been DNA tested for prcd PRA. and FN.  Normal/ clear for both.Her KC/BVA eye tests are next week.when I enquired at the practice where we are going they said she would only need the gonioscopy test for glaucoma predisposition as the DNA test covered the rest. But having seen some WCS profiles where they are health tested CPRA crops up which is why I wanted to know what the difference is and should I still have all of the KC/BVA eye tests done anyway.

Hi Martingale
Sorry about confusion - I jumped to wrong conclusion. But well done you for doing all the correct stuff !
Jan

You probably know about this site but just in case you haven't come across it this is a useful link
http://www.workingcockerhealthscreendirectory.com/cockerhealth.htm

Welcome to the forum Martingale. You may find this link of some interest:

BVA: Hereditary Eye Disease in Dogs

"We do have cases of Glacuoma but sadly no way to identify a predisposition."

Gonioscopy is the test done to identify, or not, goniodysgenesis, the predisposing abnormality to primary angle-closure glaucoma.   Could be this would only be a relevant test to do for this condition that can (not will!!) lead to glaucoma, in the Basset however.

Thank-you Admin and Harley for the links, I have a much better understanding of the eye tests now and will be getting them all done.

>Gonioscopy is the test done to identify, or not, goniodysgenesis, the predisposing abnormality to primary angle-closure glaucoma.

Unfortunately in my breed the Glaucoma found is open angle, no gonodysgenisis.