
Being able to only keep (in dog breeding terms) a small number of dogs (have 6 at present), all living within an ordinary size home, then no I don't think you could do justice to more than one breed.
I do find having all one breed an advantage with inter-dog relationships.
They will have similar levels of reactivity tolerance and just get each other more. Imagine a feisty small breed, with bigger dogs, you'd inevitably have to step in to protect the smaller dogs if any disagreements occur.
I know lots of pet homes with one or two small and large dogs and that works well, but if you have any number you really do have to separate when not strictly supervised, purely to avoid accidental damage.