
Only sure way is whn she gives birth:D Seriously though in canines this is not easy as most bitches will have some signs of phantom pregnancy, so will exhibit all the usual signs that point to pregnancy. that is nipples turning pinker, and glands becoming more defined, change in behaviour etc.
An experienced vet can feel during a short time around 3 to 4 weeks in whelp, but even then there is no certainty. Ultrasound is more reliable to confirm pregnancy, though unreliable regarding numbers. Again it depends on the skill of the vet doing the scan.