
It doesn't sound like normal behaviour to me. I only ever had one bitch not take to her pups, after a section. I removed them from her, and hand reared, as she was just distressed at having them anywhere near her. She wasn't growling, just very, very nervous of them.
In your case, assuming she had a natural birth, I would want the vet to give her the once over, rather than risk her killing the pups.