
Just to clarify (or muddy the waters) a little more, Labkolin who do MDR1 testing say that Milbemax is safe to use even in dogs with the defect MDR1 gene, but as Satincollie has said, only in the correct dose.
For anyone with a herding breed that has the MDR1 gene, or anyone with an untested herding breed...
Class A
Do not use in dogs with defect transporterIvermectin-Präparate (Diapec ®, Ecomectin ®, Equimax ®, Eqvalan ®, Ivomec ®, Noromectin ®, Paramectin ®, Qualimec ®, Sumex ®, Virbamec ®)
Doramectin-substances (Dectomax ®)
Moxidectin-substances (Cydectin ®, Equest ®)
Loperamid-substances (Imodium ®)
Class B
An interaction has been shown; use only under close control of veterinarianCytostatics ( Vinblastin, Doxorubicin, Paclitaxel, Docetaxel, Methotrexat) Immunsuppressiva (Cyclosporin A) Herzglykoside (z.B. Digoxin, Methyldigoxin ) Opioide (Morphin) Antiarrhythmika (Verapamil, Diltiazem, Chinidin) Antiemetika (Ondansetron, Domperidon)
Class C
Can be usedStronghold ®, Advocate ® and Milbemax ® only in the permitted application form and dose!