
Yes, slip matings can and do result in puppies. Your friend's best bet is to take her bitch to the vet for the termination injection. However this often brings a bitch back into season again, so she'd have to keep the bitch confined for another four weeks. Alternatively she could have the bitch spayed now - not ideal, but better than an unwanted litter.
Your post emphasises the importance of not leaving an in-season bitch unattended out of doors - very few gardens are truly safe, even though we may think they are.