
Sorry to hear about your boy. :( It depends which joint/s are infected, how badly, and whether the antibiotics can sort it out. From experience I'd suggest that you ask the vet to take a swab and analyse it to discover which antibiotic would be best - some are broad-spectrum and generally good, but some are better at targetting particular bacteria.
A few years ago my dalmatian got a stubborn infection in the bed of one nail, which spread to the joint and he had to have that toe amputated; he's fine now, thankfully. Hopefully it won't come to that with your Dane. Good luck.
:)