
I'd wait until she's around 2 days beyond the due date from the first mating (bearing in mind conception may not have taken place that day) and if nothing has happened, get her to your vet and be prepared for her to need a C.Section. For sure, small litters or singleton puppies do tend to 'sit' growing bigger by the day and making it less likely there will be a natural birth. Your vet would x-ray to see if she's empty or not, before doing a 'Section.
From my experience, false pregnancies, or phantoms tend to show after the whelping date. But that's just my experience.