
Unfortunately missed timing of mating is most common cause of missing.
Males and breeds can vary as to libido, ditto bitches.
Some will happily mate anything willing, and some bitches, especially will stand early, as early as the lh surge, so potentially 4 days before ova are able to be fertilised. Not a problem with a fit peak fertile young male that has been regularly used, and the breed has large litters.
In breeds such as my own where mating opportunites can be several years apart and often dogs used for first or second time when middle aged, several matings are more likely to produce results.
Studies have found several matings improve litter size.
Also the first ejaculate after prolonged rest will have a larger proportion of poor quality aged sperm.