Probably makes some things a little looser just as it does in humans but I wouldn't have thought it fundamentally changes the structure of anything and most changes can be undone given diet and exercise afterwards.
a friend who breeds borzois swears that bitches look better after a litter, they fill out and 'settle into their angles'. However this happens anyway, often when zois are around 3 or 4, which is usually when they would have a litter so I'm not convinced.