Ditto - start with the boiler. That is also going to be relevant to the type of shower you can or want to fit. A power shower will need good water pressure and might require you to look at pumps/water tanks too so it makes sense to consider your wet pipe work as one job...
Then, as someone else has already said, you can rethink the space you have available downstairs. Shrinking a downstairs bathroom to a cloakroom might give you options to alter your kitchen/utilty room space AND both may also require a plumber to help you move pipes and radiators. Plumbers are expensive but do like meaty jobs to work on and are more likely to give good rates for larger jobs.
As an aside we used
MyBuilder.com to help us find tradespeople last time we had work done and it was incredibly effective. You only get people who are looking for, or available for work, and I was really impressed. You must check them out, as you usually would, but we were able to choose an excellent plumber, builder and plasterer after spending weeks tying to get quotes from the usual sources