
Some of my most successful litters have been
half Uncle to niece, that is mating a bitch to her mothers half sibling.
The thinking for me is which side of the dam or sires pedigree did the desired traits in my bitch come through from most.
I would then consider a half sibling of the dam/sire strong in those traits to fix them, especially if the bitch I am mating is from an out cross.