I am just curious but is it possible for blood type incompatablities to cause fading puppy?

I have just heard of a litter of pups fading, and someone has brought up how they can be allergic to the milk and bottle feeding can save them. I have heard of this in cats (British Shorthairs because of the two blood types) but can it also be a dog problem?

http://www.dr-addie.com/Blood%20groups.htm#What%20is%20neonatal%20isoerythrolysis? That is the link to the cat disease.

I don't know much about blood types in dogs or cats but in humans there's a clash of blood types (I think one involves the mum being - and the baby being +) where their blood types are incompatible and the baby needs a transfusion at birth.  Only the second + children are affected, not the first.

Whilst there are many causes of 'fading puppies' one cause in border collies is now known to be TNS (Trapped Neurophil Syndrome) - there is a DNA test for this so worth having done (in Australia and also now Optigen in USA do it).  No excuse for the litter born last year with a pup suffering from TNS - a sad disease where the pups usually don't live much beyond 4 months.

From what I have read there are not the 4 groups[plus sub groups] in dogs as there are in humans, each vet has dogs of larger breeds they call on when a blood transfusion is required.

Greyhounds (or dogs over 30kg.. relations if possible) are the donors of choice as they tend to be universal donors. Some dogs do have different blood types but its much less common.

Looking on this link http://ahdc.vet.cornell.edu/clinpath/modules/coags/typek9.htm  it says Neonatal isoerythrolysis has been reported in DEA 1 negative female dogs (previously sensitized to DEA 1 positive cells) mated to DEA 1.1 positive male dogs so it sounds like it can happen, but not commonly!