
Hi Lori,
different dogs, different results TBH. I'd be inclined to recommend using serene-um first following a course over a week or more and then using the valerian compound as and when needed during fireworks, thunder etc.
It is a bit of a judgement call because not all dogs respond to OTC drugs at all never mind to any homeopathic or herbal remedies. However I wouldn't personally advocate giving any precribed sedatives - especially not the all too usually given ACP which I personally know to have killed two dogs in recent years as well as having heard/read of many more :(
I'm fortunate that currently the none of mine are too bothered by Guy Fawkes etc but others always responded sufficiently well to the serene-um + valerian drops when needed :)
whoops, ETA I should have mentioned chamomilla (sp) (calmolimaloy/chamoliennium

) - comes in granules or liquid - the most sensitive dog I've had only ever coped when using that -
def worth a go!
HTH, Teri